TY - JOUR AU - Feltrer, Yedra AU - Strike, Tai AU - Routh, Andrew AU - Gaze, David AU - Shave, Robert PY - 2016/05/03 Y2 - 2024/03/28 TI - Point-of-care cardiac troponin I in non-domestic species: A feasibility study JF - Journal of Zoo and Aquarium Research JA - JZAR VL - 4 IS - 2 SE - Articles DO - 10.19227/jzar.v4i2.172 UR - https://jzar.org/jzar/article/view/172 SP - 99-103 AB - <p dir="LTR" align="JUSTIFY"><span style="font-size: xx-small;">One of the main challenges faced by veterinary surgeons in the field of zoo and wild animal medicine is the lack of published reference data and validated tests for non-domestic species. In the field of cardiology the diagnostic techniques used for domestic animals are also applied to exotic species. However due to the wide range of species dealt with and their different sizes, few techniques have been validated. Recent advances in human and domestic animal medicine have shown cardiac troponin I (cTnI) to be the biomarker of choice for myocardial damage. The primary aim of this feasibility study was to determine whether the i-STAT®1 hand-held analyser can be used to identify elevations of serum and plasma cTnI in a variety of non-domestic species. The secondary aim was to explore whether elevations in cTnI were related to underlying cardiac pathology. During routine health checks at the Zoological Society of London</span><span style="font-family: Times New Roman; font-size: xx-small;"><span style="font-family: Times New Roman; font-size: xx-small;">,</span></span><span style="font-size: xx-small;"> 171 blood samples were collected from 36 different species (27 mammal, seven bird and two reptile) and were analysed for cTnI using the i-STAT®1 hand-held analyser. Concentrations of cTnI below, equal to and well above a suggested cut-off of 0.08 µg/L were observed in mammalian species. The majority of animals with concentrations of cTnI above 0.08 µg/L were subsequently shown to have pathology with potential cardiac involvement. All avian and reptilian samples were below 0.00 µg/L even though overt cardiac pathology was noted in some of these animals. In conclusion, the assessment of cTnI using the i-STAT®1 hand-held analyser shows promise as a humoral marker of cardiac pathology in mammalian species but not for avian and reptilian species. Further work is required to define species-specific reference intervals for cTnI.</span></p> ER -